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Generalised Anxiety Disorder

TREATMENT FOR GAD

GAD is now treated with drug assisted therapy and psychological therapies, simultaneously or alone. Treatment ought to commence with reassurance that the physical complaints are not symptomatic of a medical illness. Over the last decade, the pharmacological management of GAD has moved from treatment with the benzodiazepines – Valium and Serepax to the use of selective serotonin re - uptake inhibitors (SSRIs) and the serotonin and noradrenaline reuptake inhibitor (SNRI) – Venlafaxine. (See Table 3) However, the use of the benzodiazepines still has a place in the treatment of GAD.

The worry in GAD predicts that an adverse event will occur. Cognitive therapy, the most widely used psychological therapy in GAD, seeks to restrict the worry, modify the underlying thoughts and beliefs by challenging the probability that the event will occur. Behaviour therapy is directed at minimising body tension using modes of relaxation therapy.


Table 3 Drug assisted treatment for GAD

Generic name

Common brand name

Daily dose range

Generic brand name

Selective serotonin reuptake inhibitors (SSRIs)
Antidepressants
     
  • Fluvoxamine
Luvox 50 -  300mg Faverin, Movox, Voxam
  • Fluoxetine
Prozac 20 - 80mg Lovan, Genrx Fluoxetine, Fluohexal, Zactin, Auscap 20
  • Sertraline
Zoloft 50 - 200mg Xydep, Concorz, Terry White Chemists Sertraline
  • Citalopram
Cipramil 20 - 60mg Talohexal, Genrx Citalopram, Celapram, Talam
  • Paroxetine
Aropax 20 - 60mg Espar, Oxetine, Paxtine, Genrx Paroxetine
  • Escitalopram oxalate
Lexapro 10 - 20mg  

Serotonin and noradrenaline reuptake inhibitor (SNRI)
Antidepressant
     
  • Venlafaxine
Efexor - XR 75  - 300mg  

Benzodiazepines
*Antianxiety agents
     
  • Diazepam
Valium 5 - 10 mg Antenex, Ducene, Valpam
  • Alprazolam
Xanax 2 - 6mg Kalma, Alprax
  • Clonazepam
Rivotril 2.5 - 3mg Paxam

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